Amen. My mother used to send me to everyone's house that signaled measles, when there was still no vaccine for German Measles. She understood about natural immunity back in the early 60's, and the importance of me not getting it in my fertile ages.
Dr. Malone, you are my #1 trusted source on all things Covid! I eagerly await your observations and was so pleased to find you on Substack. I also subscribed to Alex Berenson and Steve Kirsch. Anyone else I should know about? Always looking for good sources. 🙂
Dr. Malone, your many interviews, conferences, postings are clearly a gift of heart, AND, PLEASE also make your own well-being an equal priority. I, for one, have so much more awareness of what's going on and of the possibilities of hope with your voice. So please take good care of yourself : ).
If we find ourselves in a world where we don't know if you're a man just because you have a "thingy"... we certainly don't know if those who have "wrangled" the title of Public Health Official aren't shills for pharmaceuticals...
I have a general question on the adaptive antibodies from the vaccine. They say vaccine effectiveness wanes after so many days/months, which I believe is measured by declining antibodies circulating over time (??) But, what about antibodies that would be recalled from memory if later presented with the virus? I haven't seen this discussed clearly anywhere and I think it is important to the discussion of waning vaccine effectiveness and whether that claim is based on clinical outcomes or on measurement of antibody titers and whether a vaccinee will still recall antibodies if later challenged with the virus but these are subsequently not effective. Can anybody with higher knowledge than me comment on this?
If I understand correctly, Geert Vanden Bossche is asserting that Omicron infection in the vaccinated may not be an end point but more of a starting point for more harmful mutations. This article also provides the most down-to-earth explanation I've seen on why the vaccinated are more of a breeding ground than the unvaccinated:
"The combination of mounting Ab titers and high viral load, within an increasing part of the vaccinated population experiencing breakthrough infections - only promotes further immune selection and dominant propagation of viral immune escape variants, which then, further improve on resisting vaccine-induced immune pressure of their infectiousness. It is, therefore, fair to assume that the recent emergence of Omicron resulted from large-scale breakthrough infections in a highly vaccinated population.
This is in sharp contrast to a situation where an unvaccinated individual contracts C19-disease. Unvaccinated individuals contract C-19 disease as a result of the virus breaking through their innate immune defense; in which case, viral transmission occurs well in advance of the appearance of a robust humoral response and, therefore, doesn’t cause immune pressure on viral infectiousness. De novo priming of anti-S Abs that are directed at the relevant circulating variant, prevents natural selection and adaptation of more infectious variants in the unvaccinated population.
Furthermore, vaccinal Abs continue to suppress innate immunity. This being said, it’s difficult to believe that recall of vaccinal Abs, in vaccinees who experience a breakthrough infection, would not accelerate the occurrence of viral resistance to the C-19 vaccines and not continue to further suppress the innate immunity of vaccinees. Recall of vaccinal Abs is inevitable given the dominant circulation of highly infectious strains. In other words, I fear that protection of vaccinees who recovered from C-19 disease and are re-exposed to the virus will be much less efficacious than the immune protection acquired by a nonvaccinated person who recovered from C-19 disease."
There is another article circulating on Substack indicating that the death rate for unvaccinated is twice that of Delta and the media is deliberately misleading (shocking). Dr. Malone, how do you interpret this data?
It's great keeping getting updates of the latest Covid developments
Thank you for the kind words and feedback!
Computer modelling - meh. Talk to Neil Ferguson about that shite.
We keep hearing from clinicians that Omicron is mild. If so, we should welcome it. It's nature's vaccination.
Amen. My mother used to send me to everyone's house that signaled measles, when there was still no vaccine for German Measles. She understood about natural immunity back in the early 60's, and the importance of me not getting it in my fertile ages.
Dr. Malone, you are my #1 trusted source on all things Covid! I eagerly await your observations and was so pleased to find you on Substack. I also subscribed to Alex Berenson and Steve Kirsch. Anyone else I should know about? Always looking for good sources. 🙂
Not to presume to speak for Dr Malone but here's a few suggestions doing outstanding COVID related analysis and reporting.
https://aaronsiri.substack.com/
https://roundingtheearth.substack.com/
https://boriquagato.substack.com/
https://disinformationchronicle.substack.com/
Thanks, I will check those out!
https://jessicar.substack.com/
Dr. Malone, your many interviews, conferences, postings are clearly a gift of heart, AND, PLEASE also make your own well-being an equal priority. I, for one, have so much more awareness of what's going on and of the possibilities of hope with your voice. So please take good care of yourself : ).
If we find ourselves in a world where we don't know if you're a man just because you have a "thingy"... we certainly don't know if those who have "wrangled" the title of Public Health Official aren't shills for pharmaceuticals...
I have a general question on the adaptive antibodies from the vaccine. They say vaccine effectiveness wanes after so many days/months, which I believe is measured by declining antibodies circulating over time (??) But, what about antibodies that would be recalled from memory if later presented with the virus? I haven't seen this discussed clearly anywhere and I think it is important to the discussion of waning vaccine effectiveness and whether that claim is based on clinical outcomes or on measurement of antibody titers and whether a vaccinee will still recall antibodies if later challenged with the virus but these are subsequently not effective. Can anybody with higher knowledge than me comment on this?
If I understand correctly, Geert Vanden Bossche is asserting that Omicron infection in the vaccinated may not be an end point but more of a starting point for more harmful mutations. This article also provides the most down-to-earth explanation I've seen on why the vaccinated are more of a breeding ground than the unvaccinated:
"The combination of mounting Ab titers and high viral load, within an increasing part of the vaccinated population experiencing breakthrough infections - only promotes further immune selection and dominant propagation of viral immune escape variants, which then, further improve on resisting vaccine-induced immune pressure of their infectiousness. It is, therefore, fair to assume that the recent emergence of Omicron resulted from large-scale breakthrough infections in a highly vaccinated population.
This is in sharp contrast to a situation where an unvaccinated individual contracts C19-disease. Unvaccinated individuals contract C-19 disease as a result of the virus breaking through their innate immune defense; in which case, viral transmission occurs well in advance of the appearance of a robust humoral response and, therefore, doesn’t cause immune pressure on viral infectiousness. De novo priming of anti-S Abs that are directed at the relevant circulating variant, prevents natural selection and adaptation of more infectious variants in the unvaccinated population.
Furthermore, vaccinal Abs continue to suppress innate immunity. This being said, it’s difficult to believe that recall of vaccinal Abs, in vaccinees who experience a breakthrough infection, would not accelerate the occurrence of viral resistance to the C-19 vaccines and not continue to further suppress the innate immunity of vaccinees. Recall of vaccinal Abs is inevitable given the dominant circulation of highly infectious strains. In other words, I fear that protection of vaccinees who recovered from C-19 disease and are re-exposed to the virus will be much less efficacious than the immune protection acquired by a nonvaccinated person who recovered from C-19 disease."
https://www.voiceforscienceandsolidarity.org/scientific-blog/q-a-4-the-coming-crisis
Adagio claims it's new antibodies will be effective against it. Hope they are right - I'm a participant in their prophylactic EVADE trial. https://trialsitenews.com/adagio-therapeutics-reports-sars-cov-2-antibody-adg20-currently-in-phase-2-3-trials-has-in-vitro-activity-against-omicron-variant/
There is another article circulating on Substack indicating that the death rate for unvaccinated is twice that of Delta and the media is deliberately misleading (shocking). Dr. Malone, how do you interpret this data?
https://igorchudov.substack.com/p/more-bad-news-on-omicron