Your references to Omicron infection in the sections preceding “B cell immunity after B.1.1.529 (Omicron) infection” are inaccurate as none of the HCWs sampled are labeled as infected.
The authors are instead bizarrely examining the question of how different doses and infections affect anti-Omicron responses before Omicron exposure. It’s …
Your references to Omicron infection in the sections preceding “B cell immunity after B.1.1.529 (Omicron) infection” are inaccurate as none of the HCWs sampled are labeled as infected.
The authors are instead bizarrely examining the question of how different doses and infections affect anti-Omicron responses before Omicron exposure. It’s a totally bewildering question for them to pursue and all the results in these sections are useless.
Note also that the authors are serially imprecise or intentionally misleading whenever it comes to describing things as being “reduced,” never specifying “compared to what” on a case by case basis. Your characterization of the “reduction” in antibody response X weeks after dosage (“ but in the case of Omicron, these levels dropped after either two or three doses of vaccine.”) is inaccurate for this reason. The authors are instead (bewilderingly) reporting that Wuhan vaccination doesn’t make a high Omicron response, especially relative to anti-non-Omicron immediately after dosage.
The results in the actual post-Omicron-wave infection sections are flawed as well. No actual confirmed variant type for infections. Unvaxxed left out for no apparent reason (so, inferences like “Post vaccination, rapid loss of any detectable T cell immunity against S1, which is the main antigen in the vaccines.” Are perilous since no comparison is provided to the unvaxxed). No longitudinal tracking to support their conclusions that Wuhan infected + “Omicron wave” infected “showed no increase” in anti-Omicron response.
Your references to Omicron infection in the sections preceding “B cell immunity after B.1.1.529 (Omicron) infection” are inaccurate as none of the HCWs sampled are labeled as infected.
The authors are instead bizarrely examining the question of how different doses and infections affect anti-Omicron responses before Omicron exposure. It’s a totally bewildering question for them to pursue and all the results in these sections are useless.
Note also that the authors are serially imprecise or intentionally misleading whenever it comes to describing things as being “reduced,” never specifying “compared to what” on a case by case basis. Your characterization of the “reduction” in antibody response X weeks after dosage (“ but in the case of Omicron, these levels dropped after either two or three doses of vaccine.”) is inaccurate for this reason. The authors are instead (bewilderingly) reporting that Wuhan vaccination doesn’t make a high Omicron response, especially relative to anti-non-Omicron immediately after dosage.
The results in the actual post-Omicron-wave infection sections are flawed as well. No actual confirmed variant type for infections. Unvaxxed left out for no apparent reason (so, inferences like “Post vaccination, rapid loss of any detectable T cell immunity against S1, which is the main antigen in the vaccines.” Are perilous since no comparison is provided to the unvaxxed). No longitudinal tracking to support their conclusions that Wuhan infected + “Omicron wave” infected “showed no increase” in anti-Omicron response.